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Quintessence International



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Quintessence Int 50 (2019), No. 3     22. Feb. 2019
Quintessence Int 50 (2019), No. 3  (22.02.2019)

Page 208-213, doi:10.3290/j.qi.a41973, PubMed:30773573

Oral rehabilitation in a patient with sclerotic-phenotype chronic graft versus host disease: a case report
Etebarian, Arghavan / Mirshamsi, Hamid / Sadeghi, Hanieh Sadat / Hemmati, Fatemeh
Acute myeloid leukemia is a bone marrow malignancy in which blasts count increases by more than 20% in the bone marrow. Allogeneic hematopoietic stem cell transplantation (alloHCT) is a treatment option for these patients with high risk of graft versus host disease (GVHD) development. Chronic GVHD (cGVHD) often mimics a variety of autoimmune conditions such as systemic lupus erythematous or systemic sclerosis. Sclerotic cGVHD has a wide spectrum of oral manifestations, including mucosal atrophy, microstomia, and hyposalivation. This report presents a full-mouth implant-retained reconstruction in a 35-year-old male patient who had undergone alloHCT for treatment of acute myeloid leukemia and developed sclerotic cGVHD afterwards. Implant-retained prosthetics might be a practicable treatment for patients with these complications.

Keywords: dental implants, graft versus host disease, hematopoietic stem cell transplantation, microstomia, xerostomia