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Quintessence International



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Quintessence Int 46 (2015), No. 3     23. Jan. 2015
Quintessence Int 46 (2015), No. 3  (23.01.2015)

Page 247-253, doi:10.3290/j.qi.a32921, PubMed:25328923

Indications and procedures for direct immunofluorescence biopsies of the oral mucosa
Tapia, Jose Luis / Neiders, Mirdza E. / Suresh, Lakshmanan
A definitive diagnosis is crucial for management of any oral mucosal disease. Direct immunofluorescence (DIF) is a valuable diagnostic aid for immune-mediated blistering diseases and systemic connective tissue diseases of the skin and the mucosa. This paper gives an overview of the DIF biopsy technique for oral lesions and provides a background for the clinician to optimize the utilization of DIF biopsy. The key characteristic diagnostic findings of DIF of specific mucosal diseases are also discussed.

Keywords: direct immunofluorescence, immune-mediated blistering diseases, oral vesiculobullous disease, oral biopsy technique, systemic connective tissue diseases