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Quintessence Int 45 (2014), No. 10     26. Sep. 2014
Quintessence Int 45 (2014), No. 10  (26.09.2014)

Page 869-874, doi:10.3290/j.qi.a32639, PubMed:25191673


Mandible reconstruction using rhBMP-2: Case report and literature review
Lustosa, Rômulo Maciel / Iwaki, Lilian Cristina Vessoni / Tolentino, Elen de Souza / Chicarelli da Silva, Mariliani / de Oliveira Lazarin, Rafael / Iwaki Filho, Liogi
Recombinant human bone morphogenetic protein-type 2 (rhBMP-2) is used in oral and maxillofacial procedures due to its endochondral bone formation capacity, and this is also the reason for its use off-label in jaw reconstruction. This study reports a case of an extensive central giant cell lesion along the mandibular body and symphysis. Treatment consisted of enucleation and curettage followed by off-label use of rhBMP-2 associated with bovine bone xenograft. The literature concerning mandibular reconstruction using rhBMP-2 was also reviewed.

Keywords: bone graft, bone morphogenetic protein-type 2, mandibular reconstruction, xenograft