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Quintessence Int 43 (2012), No. 10     1. Nov. 2012
Quintessence Int 43 (2012), No. 10  (01.11.2012)

Page 901-906, PubMed:23115769


The influence of chlorhexidine on the antibacterial effects of MTA
Mittag, Sven-Georg / Eißner, Christof / Zabel, Lutz / Wrbas, Karl-Thomas / Kielbassa, Andrej M.
Objective: To investigate the influence of chlorhexidine in different concentrations when mixed with mineral trioxide aggregate gray (MTA-G) or white (MTA-W). The antibacterial effect on Enterococcus faecalis was used as the primary parameter.
Method and Materials: Similar to the agar diffusion test, Mueller-Hinton agar plates were inoculated with E faecalis (ATCC 19433), and 14 groups (n = 21) were prepared. The specimens consisted of MTA-W and MTA-G, and these were enriched with chlorhexidine concentrations of 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, and 2.0%. Pure MTA-W and MTA-G (each combined with distilled water) were used as controls. After incubation periods of 24 and 48 hours, the inhibiting areolae were measured.
Results: Pure MTA-W, in contrast to pure MTA-G, had no bactericidal effects. With increasing chlorhexidine concentrations of up to 1.5%, a linear increase in bactericidal activity was observed. In contrast, MTA-G showed only a low self-bactericidal influence, and the antibacterial effects with increasing chlorhexidine concentrations were significantly lower than those of MTA-W (P < .001).
Conclusion: When mixed with distilled water, pure MTA-G revealed a low bactericidal effect against E faecalis. The use of chlorhexidine with MTA mixtures leads to an antibacterial effect against E faecalis, and within the first 48 hours, this effect is significantly higher in combination with MTA-W when compared with MTA-G.

Keywords: chlorhexidine, Enterococcus faecalis, microbiology, mineral trioxide aggregate