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Quintessence International



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Quintessence Int 22 (1991), No. 12     1. Dec. 1991
Quintessence Int 22 (1991), No. 12  (01.12.1991)

Page 961-966

Systemic effects of nickel-containing dental alloys: analysis of nickel levels in serum, liver, kidney, and oral mucosa of guinea pigs
Sahmali / Kural / Kilic
For economic reasons, nickel alloys are in widespread use in dentistry. However, allergic reactions have been observed in nickel-sensitive patients. In this study, absorption of nickel in the serum, liver, kidney and oral mucosa of guinea pigs was examined. Guinea pigs experimentally sensitized to nickel showed significantly higher levels of nickel in serum than did control animals. Levels of nickel in experimental and control animals were found to increase over time.