Patients with think nonresilient mucosa, poor ridge morphology, chronic xerostomia, and acquired or congenital defects are candidates for soft denture liners. Soft denture liners may be placed during fabrication of the new denture or during relining of the existing dentures. Soft mandibular denture liners are ideal for senior patients with resorbed mandibular ridges who need replacement of existing dentures to correct excessively closed vertical dimension of oclusion and for patients who have maxillry complete dentures and mandibular natural teeth, severe loss of maxillary ridge, and clenching habits. Soft denture liners should be used only when needed because of their short service life. However, for those patients who cannot tolerate hard denture bases, soft liners are an appropriate alternative treatment.