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Quintessence International
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Quintessence Int 29 (1998), No. 9     1. Sep. 1998
Quintessence Int 29 (1998), No. 9  (01.09.1998)

Page 555-563


The efficacy and safety of a 10% carbamide peroxide bleaching gel
Matis / Cochran / Eckert / Carlson
Objective: A 6-month, double-blind study was undertaken to assess the efficacy and safety of a 10% carbamide peroxide gel designed for at-home tooth bleaching. Method and materials: Sixty patients were randomized into two equal subgroups balanced by age, gender, and oral health status. Shade guide measurements, color transparency photographs, and colorimeter readings were taken and evaluated at baseline and 1, 2, 3, 6, 12, and 24 weeks. The active phase of treatment lasted 14 days. Results: At 22 weeks postbleaching (week 24 of the study), patients receiving the active agent had a 14.1 rank order difference in the shade guide from baseline, and 66% had a clinically observable color change as determined by photographic assessment. They also had a measurable, statistically significant color change from baseline to 6 months of AE* = 5.0. The tooth color of maxillary incisors stabilized at week 6 and maxillary canines at week 12. The mean color change lost from weeks 2 to 24 was 45% (in A E*). Transient tissue and tooth sensitivity, noted in some pat ients, resolved after treatment was completed. Conclusion: The product tested is an effective and safe tooth-whitening agent.