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Quintessence Int 51 (2020), No. 2     17. Jan. 2020
Quintessence Int 51 (2020), No. 2  (17.01.2020)

Page 100-107, doi:10.3290/j.qi.a43865, PubMed:31942571


Association between type 2 diabetes mellitus and the evolution of endodontic pathology
Ríos-Osorio, Néstor / Muñoz-Alvear, Hernan Darío / Montoya Cañón, Santiago / Restrepo-Mendez, Silvia / Aguilera-Rojas, Sandra E. / Jiménez-Peña, Oscar / García-Perdomo, Herney Andrés
Objective: The purpose of the present study was to assess the influence of type 2 diabetes mellitus (DM) on the evolution of pulpal and periapical pathology.
Method and materials: Two reviewers independently conducted a systematic search for articles published between 1 January 2001 and 31 December 2018 on MEDLINE/PubMed, ISI Web of Science, and Scopus databases. An additional manual search was also carried out.
Results: Ten studies fulfilling the inclusion criteria were included in the review (two longitudinal studies with 1-year follow-up comparing the success of primary root canal treatment between type 2 diabetic patients and non-diabetic patients, and eight cross-sectional studies). Analysis of the ten studies showed that inadequate control of type 2 DM may predispose and influence the inflammatory pulpal and periapical disease evolution.
Conclusions: The present systematic review suggests that there are biologic bases to suggest that type 2 DM may act as a risk factor for developing an endodontic pathology, affecting the course of the disease in terms of susceptibility, prevalence, progression, and tissue healing capacity as a consequence of a disrupted immune response. However, more well-designed clinical investigations carrying out suitable research methodologies are needed to elucidate the influence of type 2 DM on the pulpal and periapical disease evolution.

Keywords: dental pulp, diabetes, endodontics, periapical pathology, systematic review