We are using cookies to implement functions like login, shopping cart or language selection for this website and to create anonymized statistical reports of the usage. You will find more information in our privacy policy. OK, I have understood
Quintessence International
Login:
username:

password:

Plattform:

Forgotten password?

Registration

Quintessence Int 45 (2014), No. 8     20. July 2014
Quintessence Int 45 (2014), No. 8  (20.07.2014)

Page 703-711, doi:10.3290/j.qi.a32240, PubMed:25019114


Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial
Vano, Michele / Derchi, Giacomo / Barone, Antonio / Covani, Ugo
Objective: The present double-blind randomized clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.
Method and Materials: 105 subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: 1) nano-hydroxyapatite 15% toothpaste, fluoride-free; 2) fluoride toothpaste; 3) placebo. Groups 1, 2, and 3 were instructed to brush their teeth for 2 minutes twice a day with the provided toothpaste. The participant's dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analog scale (VAS) was used.
Results: Significantly lower values of cold air sensitivity and tactile sensitivity (P < .001) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significantly (P < .001) lower values of sensitivity were reported for group 1 compared to groups 2 and 3, at 2 and 4 weeks respectively. The VAS scores were significantly lower (P < .001) in the test group at 2 and 4 weeks compared to baseline and to the control groups.
Conclusion: The findings of the present study encourage the application of nano-hydroxyapatite in fluoride-free toothpaste as an effective desensitizing agent providing quick relief from symptoms after 2 and 4 weeks.
fulltext (no access granted) order article as PDF-file (20.00 €)