Objective: The restoration of non-caries cervical lesions has long been a challenge. Until recently, compomers were the restorative materials of choice. The aim of this in-vivo study was to evaluate the long-term clinical performance of Dyract restorations in non-caries cervical lesions.
Method and Materials: Forty-two patients with Dyract restorations of non-caries cervical lesions performed in 1995 by the same operator were included in this in-vivo retrospective study. After 20 years, restorations were evaluated by two calibrated examiners following the USPHS criteria modified by Ryge.
Results: After 20 years, 38 of the 54 restorations included in this study remain in service (70.4%). Debonding was the cause of all failures. Marginal adaptation and marginal discoloration were the categories with poor values.
Conclusion: Dyract restorations can be considered a treatment option for non-caries cervical lesions, because they show good long-term clinical performance for 20 years.
Clinical Relevance: Dyract restorations continue to be an option to restore non-caries cervical lesions, due their good long-term clinical performance and the ease of the clinical procedure. The survival rate of these Dyract restorations was high after 20 years (70.4%). However, the limitations of marginal discoloration, marginal adaptation, and color match should be considered.

Keywords: class V, compomer, Dyract, longevity, non-caries cervical lesion, polyacid-modified composite resin

For the past several thousand years, until development of the titanium dental implant, only a few missing teeth were replaced successfully in a very small number of individuals. Nowadays, placement of dental implants has become sufficiently commonplace that there is a need to interchange information between what we know about periodontal health and disease and what we know about health and disease involving dental implants. This review discusses the similarities and differences between teeth and dental implants with regards to anatomy, biology, physiology, and pathologic processes. The concept of biologic width is discussed in the context of interaction of periodontal and peri-implant tissues with microbial products produced by periodontal biofilms. The periodontal microbiome is discussed as networks of organisms interacting not only with periodontal and peri-implant tissues, but also with each other as networks of competing organisms. Overall, the transfer of biologic knowledge from what we know about peri-implantitis and what we know about periodontitis should help to develop new directions for biologic understanding about both health and disease of teeth and dental implants.

Keywords: bone, bone loss, gingival health, plaque

Objective: This systematic review aimed to investigate the influence of gene polymorphisms on the development of gingival overgrowth in renal transplant patients treated with cyclosporin A.
Method and Materials: Electronic and hand literature searches were conducted by two independent reviewers in MEDLINE-Pubmed, Cochrane Library, ISI Web of Science, and SCOPUS Elsevier for prospective (case-control studies, cohort studies), cross-sectional, and retrospective studies published up to June 2016 (first week) in any language. Data were reviewed and extracted in duplicate independently. Methodologic quality assessment of the included studies was performed during the data extraction process.
Results: Due to the estimated high risk of bias and the heterogeneity of the included studies in regards to the variety of medications administered to study patients, a systematic review of the literature and not a meta-analysis of the data was performed. Fourteen articles meeting study inclusion criteria were selected for data extraction that examined the association between various genetic polymorphisms and gingival overgrowth in kidney transplant patients receiving cyclosporin A. Interleukin-1A, interleukin-10, transforming growth factor-β1 and androgen receptor gene polymorphisms may have a significant effect on an individual susceptibility to cyclosporin A-induced gingival overgrowth in renal transplant patients.
Conclusion: Genetic polymorphisms seem to affect the development of cyclosporin A-induced gingival overgrowth in renal transplant patients. Pharmacogenetics and pharmacogenomics have the potential to determine the clinical outcome of a medication, the drug efficacy, and adverse drug reactions such as gingival overgrowth.

Keywords: cyclosporin, gingival overgrowth, genetic predisposition