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Quintessence Int 47 (2016), No. 4     24. Mar. 2016
Quintessence Int 47 (2016), No. 4  (24.03.2016)

Page 319-327, doi:10.3290/j.qi.a34974, PubMed:26504904


Topical sulfasalazine for unresponsive oral lichen planus
Jeong, Sung-Hee / Na, Hee-Sam / Park, Su-Hyeon / Ahn, Yong-Woo / Chung, Jin
Objective: The purpose of this study was to evaluate the usefulness of topical sulfasalazine in the treatment of oral lichen planus (OLP) resistant to corticosteroid therapy.
Method and Materials: Twenty-one unresponsive OLP patients were treated with topical sulfasalazine 3 times a day for 4 weeks. Each patient's symptoms and lesion size were evaluated at the beginning of therapy, and then after 4 weeks to determine the efficacy of topical sulfasalazine. Inflammatory cytokines levels in saliva were measured by ELISA.
Results: Seventeen patients (81%) reported improvement of discomfort and 12 patients (57%) had lesions decrease in size over 50%. Patients who had higher levels of IL-1β and IL-8 were more responsive to topical sulfasalazine therapy.
Conclusion: Topical sulfasalazine should be considered when OLP does not respond to corticosteroid therapy. Furthermore, high concentrations of IL-1β and IL-8 in the saliva are useful indicators for the application of topical sulfasalazine in OLP patients refractory to steroid treatment.

Keywords: sulfasalazine, topical application, unresponsive oral lichen planus
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